Preface to the monograph
Quantum Consciousness of the Linguistic Wave Genome. Theory and practice.
Dr. Peter P. Garyaev.
Quantum Consciousness of the Linguistic-Wave Genome. Theory and Practice.
One of the main provisions of the monograph is that the M. Nirenberg and F. Crick gene-protein model of the genetic code is strategically false. This model is universally accepted and represents a standard in genetic science. And why is this model based on E. Coli genome studies and not of a human or any other biosystem? There are dozens of different genetic codes from many biosystems (including mitochondrial ones). And all of them differ in some codons from the standard model and from each other. However, this is not the main question. And currently, it is believed that despite their diversity, the codes are stationary structures in the sense of accuracy and consistency of amino acid and stop position.
The first doubts in the standard code model of unambiguous encoding of amino acids and stop positions were sown by the proven fact that the UUU codon of E. coli codes two different amino acids – phenylalanine and leucine. Then, similar ambiguity was found in UGA codon of Ciliated Infusoria, coding two different amino acids – cysteine and selenocysteine. The duality of coding has been experimentally demonstrated in two organisms – (E). coli and Ciliated Infusoria and has remained unexplained. In 1997, in my first Russian edition of the monograph “The Wave Genetic Code”, I explained this phenomenon is the result of the ribosome’s ability to interpret the ambiguous triplet’s meaning through reading the mRNA and determining it’s correct context. There are 32 of such ambiguous triplets in the standard code (the other 32 were considered to be unambiguous and called synonymous or syncodons). Thus, these ambiguous ones were called nonsynonymous. These two codon families are symmetric in the two-dimensional space of the standard code table. My initial interpretation of gene coding ambiguity was far from complete, and this turned out to be much more complicated and interesting, and I developed this topic in four articles in the Open Journal of Genetics, which are part of this monograph. Nobody ever noticed the existing problem of ambiguous coding by 32 nonsynonymous codons. They are the hybrids of 32 synonymous and 32 nonsynonymous codons. Nonsynonymous codons have properties of homonyms, but in combination with properties of synonyms, i.e., we observe hybridization of synonymous and homonymous properties and functions. In the standard table of the protein code, they form a special group of 32 hybrid Synonymous-Homonymous codons, which I called SYHOM codons. They have previously unknown strategic functions in protein biosynthesis. Unfortunately, this was not obvious to the Fathers of the standard model of the protein genetic code, (F). Crick and M. Nirenberg, resulting in extremely negative consequences.
Let us describe this problem in a nutshell. Analysing the standard code table and considering the obvious and proven redundancy of amino acid coding by syncodons, (F). Crick formulated the so-called Wobble Hypothesis. Its main postulate is as follows: The 3′-nucleotide in nonsynonymous codons (SYHOMs) “wobbles”, that is, it can be any of the four possible ones. Wherein, (F). Crick implied virtual (or imaginary) wobbling, i.e. substitutions of nucleotides in the 3′-position and in SYHOM codons as a part of mRNA. If we assume that such substitutions are taking place (for example, due to mutations), then, this situation becomes overly complex and ambiguous. But it was not considered by F. Crick. And it was his big mistake. If such substitutions of 3′-nucleotides in SYHOM’s are taking place, then, it states the obvious: the ambiguous nature of coding of amino acids and stop positions. But this ambiguity is resolved by the contextual influence of mRNA transcripts – gene copies. In this case, a semantic encoding of the SYHOM codon takes place similar to the following example: LONDON is written, but we read it as PARIS, since it was PARIS that was meant by the mRNA context. This is a simple analogy from linguistics. We unmistakably understand the speech of a person who mispronounces some letters in words (analogues of mRNA mutations), if we know in advance what it is about. THE WHOLE corrects the PART if it is wrong. Such is the simplicity of the wisdom of the genetic code. Or, if you like, the wisdom of simplicity.
A lack of understanding of this fact is typical for modern genetics and molecular biology. What is the role of misunderstood functions of 3′-nucleotides in SYHOM codons? They clearly highlight the fundamental phenomenon of switching the genetic nature of protein coding into something similar to the speech/text encoding in the triad of DNA genes mRNA gene transcripts Proteins, where each of the above represent real speech-text structures. SYHOM codons represent a stage for playing out the strategic scenario of switching the protein code into the infinite semantic realms of real speech-text genes via the means of 3′-nucleotide. In this case, the following rule is implemented: during virtual (or real – mutant, artificial) changes in their own 3′-nucleotides, SYHOM codons are invariant in the meanings, programmed by mRNA. This scenario is realized only through the act of mRNA reading by the ribosome. The standard genetic code table can and should be correctly “understood” by a protein synthesizing system only in the dynamics of protein biosynthesis. Apparently, this applies to all protein codes of all biosystems. The described functions of SYHOM codon protein biosynthesis in a biosystem are the elementary primary fractals of Consciousness, creating the inner speech of biosystems in a triad of dialects: DNA genesmRNA gene transcriptsProteins. In its highest form, this is manifested in powerful protein synthesis in brain neurons, especially, in the human cerebral cortex. These proteins have short lifetimes and rapidly degrade, transforming into holograms according to the Renato Nobili Model. By doing this, they keep their information content in a quantum form. SYHOM codons ability to create DNA speech-like genetic structures is an evolutionary leap for humans as well as the biota of the Earth as a whole. At the same time, these are the origins of the human consciousness and speech formation. On the other hand, by studying and understanding the grammar of the genes, it is possible to create artificial genes with the targeted text programs. But here we must be ethically and scientifically careful …
Another direction of genetics and molecular biology set by A.G. Gurvich almost 100 years ago, which we develop and demonstrate in this study, is the fundamental phenomena of the gene’s material-wave dualism and holographic nature of genetic information. In fact, these two factors are the reflection of the same phenomenon in different forms: the multilevel nonlocality of genetic information. It is nonlocal at the social, organismic, tissue, cellular, DNA-mRNA-protein-textual, holographic and quantum levels. All levels of nonlocality, except for holographic and quantum, can be easily logically deduced. We have experimentally demonstrated holographic nonlocality. Quantum nonlocality was demonstrated indirectly by our experiments and requires additional research and theoretical reasoning that we are working on now. Our main and first work on indirect proof of the presence and real functions of wave genes is our work in Toronto in 2001-2002. We set up an experiment on wave triggering of pancreatic regeneration in dozens of rats (after induction of alloxan diabetes, accompanied by pancreatic degradation and death of animals from type 1 diabetes as a control group). At the stage of the onset of animal death, we irradiated them with the wave information read by a special laser from the metabolome of isolated pancreatic preparations, which included genetic information about the pancreas of newborn rat pups of the Vistar genetic line. The information was a secondary electromagnetic field of the LGN-303 laser. It contained a spintronic component associated with the dynamic polarization modulation of two orthogonal optical modes of laser radiation. This secondary field represents Modulated Broadband Electromagnetic Radiation (MBER). Its effect on dying rats led to a rapid normalization of their condition and in situ regeneration of their pancreas with a complete normalization of glucose biosynthesis. This is a precedent. The described experiments involved the following MBER performance features:
1. Low power MBER radiation – fractions of milliwatts at a frequency of 80 kHz
2. Remote exposure – meters to 10+ kilometres
3. Addressed influence on targeted triggering of regeneration processes in normal pancreas
These factors and many other MBER genetic effects, suggest that the gene bioactive MBER manifestation is an act of MBER spintronic activity, since the power density of MBER flow is very low and quadratically decays with distance from the radiation source. Moreover, Toronto has a large background radiation of kilohertz radio waves. However, the subtle quantum details of such remote targeted transfer of working genetic information remain the subject of research. We have published two theoretical works with theoretical physicists, with I.V. Prangishvili and others [IV. Prangishvili, P. P. Gariaev, G.G. Tertyshniy, V.V. Maksimenko, A.V. Mologin, AND THE. Leonova, E.R. Muldashev. Spectroscopy of radio wave emissions from localized photons: quantum non-local bioinformation processes. Sensors and systems, 2000, No. 9(18) https://mir.zavantag.com/jurnalistika/59678/index.html], and with A.A. Korneev [A.A. Korneev, P. P. Gariaev. Aspects of gene wave translation, 2014. https://wavegenetics.org/en/researches/aspektyi-volnovoy-translyatsii-genov/]. We reproduced the Toronto results in Nizhniy Novgorod, Russia, in 2012 in our experiments with N. Kokaya, which became a basis for a PhD defense. In addition to these experiments, we obtained previously unknown data on tooth regeneration in dogs and the spinal cord in humans. In all these cases, we used stem cell programming for tooth and spinal cord regeneration, which have both have become precedents.
In all these works one problem remained unresolved: do we really translate genes in a quantum way, or do we just initiate the biosynthesis response in the genes of a MBER-receiving biosystem? It was necessary to obtain direct evidence that we are working with the quantum equivalents of genes, predicted by A.G. Gurvich. And we have obtained evidence through MBER gene introduction into Polymerase Chain Reaction (PCR). In the first stage we introduced MBER of plasmid DNA fragment of 547 bp into PCR. After that, we sequenced obtained DNA product and found that it was 99% identical to the original plasmid DNA. Then, we did the same with MBER of human pancreatic gene cells and sequenced the resulting DNA products. They also turned out to be 98-99% identical to the original genes. Thus, we managed to prove that genes can be converted from a wave state to a material state and vice versa in the PCR system. The material-wave gene superposition becomes possible under certain conditions: the genes were converted into an electromagnetic field, which contained photon-MBER genetic information from living cells or DNA preparations. Another characteristic of the existence of genes in a physical field (MBER) is their fluctuation in time in the PCR system: the quantitative yields of DNA plasmid and genes products in the PCR system may vary from zero to maximum. The assumption is that this quantitative fluctuation is manifestation of quantum superposition of quantum states: material (gene) – wave (MBER field).
There is a possibility that COVID-19 genes behave in the same way in vivo, causing inconsistency of PCR tests for its presence in the body of an infected person. This same phenomenon might explain emerging and disappearing Coronavirus waves during the pandemic. In a few words, here comes another endless area of research related to the existence of quantum forms materials such as DNA, genes and genomes. There is lots of work ahead…
P. P. Gariaev
Acad. of The Academy of Natural Sciences
Acad. of The Russian Academy of Medical and Technical Sciences
Acad. of The International Academy of Ecology and Life Safety