Фрактальность интеллекта

The code model, there is one key contradiction, that Cry in 1953. trying to remove by using the so-called. «Vobl hypothesis». It postulates a mixed match codons to amino acids in the gene-encoded proteins and talks about the possibility of not canonical and random mating, the first nucleotide RNA transport antikodona (tRNA) with the third nucleotide of RNA codons (mRNA) When it aired in a protein. Simply put, the biosynthesis of proteins is sometimes able to lax compliance codon-antikodonovyh nucleotide at this position. That means, What are non-canonical base pair , not differ significantly according to the geometrical parameters (Guanine-Uridine, etc). In addition, of Vobl-Hypothesis, and just out of the Krikovskoj scheme (model) code, automatically be, in kodonah (triplets) only the first two genes, nucleotide (Dubal) encode the sequence of amino acids in the protein chains. Still others kodonovye nucleotides, not involved in amino acid sequence in proteins. These third, Although deterministic hard DNA, but allow arbitrary, random, No canonical pairing with the first nucleotides of RNA transport antikodonov, transferring amino acids. So these first nucleotides antikodonov can be any of 4-piece possible. Therefore, the third nucleotides in kodonah and mate with them first in antikodonah, have no sign of character and play the role of steric crutches ", fill the empty space in the codon-antikodonovyh cords. In short, the first nucleotide in antikodonah accident, "vobliruet" is from the English ' wobble ' (swing, Oscillation, wobbling). This is very important and tell you why. Since only 64 codons, and amino acids 20, the result is a glut of codons, and encoding of doublet. This excess, using linguistic analogy, is called synonymy, i.e. several doublet encode the same amino acid, from here, it is clear the existence of izoakceptornyh transport RNA (tRNA), transferring amino acids on a-site of Ribosomes. Such a sinonimičeskaâ generosity even good-this is a redundancy of information. But when protein synthesis is inevitably situations arise, When the same sometimes Doublets in kodonah RNA information, forced to somehow encode different amino acids and/or stop codons. Let me remind you, that third and first nucleotides in codon-antikodonovoj "kostyl′noj" bundle are out of sign "games", and this gives rise to a linguistic ambiguity, i.e. the situation regarding Homonymy. As, for example, for the word "Kosa", when its meaning is ambiguous. And, accordingly,, before the Ribosome, reading the same (homonymous) sometimes Doublets codons, raises the task of choosing from two different amino acids, portable tRNA, a single "correct" amino acids and/or stop signal. If the choice is incorrect-the protein will be anomalous, that can lead to metabolic catastrophe and death of the organism. How does the right choice? And he, as set, correct and up to 99,999% accurate. The Ribosome is almost no mistakes, and it seemed, should be, If the auto-follow model code! Model s it does not explain the crying.. And f. the cry it is seen and recognized in their, published shortly before his death, flashback, but just as a piece of fig Vobl Hypothesis. And all subsequent genetics did not comment on this gaping hole in the model code: the model is controversial, not accurate, but the synthesis of proteins, anyway, full proof. And only in 1978. the Swede Ulf Lagerkvist first openly stated this contradiction in the code model . But also not proposed anything Lagerkvist clear in the explanation, not aggravated the problem, but only found her. All satisfied, the synthesis of proteins-the exact process and require a larger model Krikovskoj, kind of like, and did not require. "Caesar's wife, above suspicion". And then there were the work of TN. contextual translation of mRNA to Ribosomes orientations. It was the moment of truth. It was experimentally shown, the choice of amino acids by the Ribosome in the homonymous and other situations depends not only on the doublet of codons, but the context of mRNA. Just like in human speech (texts), When, for example, the said homonym "Kosa" acquires a precise meaning only in the context of an entire phrases or sentences. This fundamental fact biologists again only stated. And all. No analysis, Why is this happening and what it means.